Serge Vakulenko (
vak) wrote2025-08-24 09:23 pm
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Про суперкомпьютер 40-летней давности
В советском союзе пытались повторить такую ЭВМ. Называлась ССБИС или "машина Мельникова". Не вышел каменный цветок.
$ grep -i insulin human_swissprot_proteins.tsvА вот скрипт, показывающий структуру указанного протеина: get_protein_sequence.py. Опробуем на инсулине:
F8WCM5 Insulin, isoform 2 INS-IGF2
O00425 Insulin-like growth factor 2 mRNA-binding protein 3 IGF2BP3
O14654 Insulin receptor substrate 4 IRS4
O15503 Insulin-induced gene 1 protein INSIG1
P01308 Insulin INS
P01344 Insulin-like growth factor 2 IGF2
P05019 Insulin-like growth factor 1 IGF1
P06213 Insulin receptor INSR
P08069 Insulin-like growth factor 1 receptor IGF1R
P08833 Insulin-like growth factor-binding protein 1 IGFBP1
P09565 Putative insulin-like growth factor 2-associated protein N/A
P14616 Insulin receptor-related protein INSRR
P14735 Insulin-degrading enzyme IDE
P17936 Insulin-like growth factor-binding protein 3 IGFBP3
P18065 Insulin-like growth factor-binding protein 2 IGFBP2
P22692 Insulin-like growth factor-binding protein 4 IGFBP4
P24592 Insulin-like growth factor-binding protein 6 IGFBP6
P24593 Insulin-like growth factor-binding protein 5 IGFBP5
P35568 Insulin receptor substrate 1 IRS1
P35858 Insulin-like growth factor-binding protein complex acid labile subunit IGFALS
P51460 Insulin-like 3 INSL3
P61371 Insulin gene enhancer protein ISL-1 ISL1
Q01101 Insulinoma-associated protein 1 INSM1
Q14641 Early placenta insulin-like peptide INSL4
Q16270 Insulin-like growth factor-binding protein 7 IGFBP7
Q6B9Z1 Insulin growth factor-like family member 4 IGFL4
Q6U949 Putative insulin-like growth factor 2 antisense gene protein IGF2-AS
Q6UW32 Insulin growth factor-like family member 1 IGFL1
Q6UWQ7 Insulin growth factor-like family member 2 IGFL2
Q6UXB1 Insulin growth factor-like family member 3 IGFL3
Q86XT9 Insulin-like growth factor-binding protein 3 receptor TMEM219
Q8TDV5 Glucose-dependent insulinotropic receptor GPR119
Q8WX77 Insulin-like growth factor-binding protein-like 1 IGFBPL1
Q96A47 Insulin gene enhancer protein ISL-2 ISL2
Q96T92 Insulinoma-associated protein 2 INSM2
Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 IGF2BP1
Q9Y4H2 Insulin receptor substrate 2 IRS2
Q9Y581 Insulin-like peptide INSL6 INSL6
Q9Y5Q6 Insulin-like peptide INSL5 INSL5
Q9Y5U4 Insulin-induced gene 2 protein INSIG2
Q9Y6M1 Insulin-like growth factor 2 mRNA-binding protein 2 IGF2BP2
$ python3 get_protein_sequence.py P01308Каждая буква обозначает аминокислоту:
Fetching protein sequence for UniProt accession: P01308
UniProt data retrieved for P01308: Insulin
Saved sequence to protein_sequences.fasta
$ cat protein_sequences.fasta
>P01308 | Insulin | UniProt Protein Sequence
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
1-е основание | 2-е основание | 3-е основание | |||||||
---|---|---|---|---|---|---|---|---|---|
U | C | A | G | ||||||
U | UUU | (Phe) Фенилаланин | UCU | (Ser) Серин | UAU | (Tyr) Тирозин | UGU | (Cys) Цистеин | U |
UUC | UCC | UAC | UGC | C | |||||
UUA | (Leu) Лейцин | UCA | UAA | Стоп | UGA | Стоп | A | ||
UUG | UCG | UAG | Стоп | UGG | (Trp) Триптофан | G | |||
C | CUU | CCU | (Pro) Пролин | CAU | (His) Гистидин | CGU | (Arg) Аргинин | U | |
CUC | CCC | CAC | CGC | C | |||||
CUA | CCA | CAA | (Gln) Глутамин | CGA | A | ||||
CUG | CCG | CAG | CGG | G | |||||
A | AUU | (Ile) Изолейцин | ACU | (Thr) Треонин | AAU | (Asn) Аспарагин | AGU | (Ser) Серин | U |
AUC | ACC | AAC | AGC | C | |||||
AUA | ACA | AAA | (Lys) Лизин | AGA | (Arg) Аргинин | A | |||
AUG | (Met) Метионин | ACG | AAG | AGG | G | ||||
G | GUU | (Val) Валин | GCU | (Ala) Аланин | GAU | (Asp) Аспарагиновая кислота | GGU | (Gly) Глицин | U |
GUC | GCC | GAC | GGC | C | |||||
GUA | GCA | GAA | (Glu) Глутаминовая кислота | GGA | A | ||||
GUG | GCG | GAG | GGG | G |
OШИБKИ HПK CBOБ ПEPEM AДPEC KOMAHДA A ИCП N ГEH N ИCX METKA OПEPAЦИЯ OПEPAHД KOMMEHTAPИЙ 0001 0001 TEST START 1 001 00001 00 010 0005 0002 0002 XTA =B’4’ 00 010 0006 0003 0003 XTA =B’1’ 00002 00 010 0007 0004 0004 XTA =B’7’ 00 010 0010 0005 0005 XTA =B’3’ 00003 00 010 0011 0006 0006 XTA =B’6’ 00 010 0012 0007 0007 XTA =B’2’ 00004 00 010 0013 0008 0008 XTA =B’5’ 00 22 0009 0009 FIN 00005 0000000000000004 00006 0000000000000001 002 00007 0000000000000007 00010 0000000000000003 00011 0000000000000006 00012 0000000000000002 00013 0000000000000005
BREEDING:,NAME, C* C*** 1.10.85. A.П.CAПOЖHИKOB C* ( C ПOДAЧИ P.EГИKЯHA ) C* C* *CALL BREEDING:NAME(N1,N2,...,NN) C* "PAЗMHOЖEHИE" ЗAДAHHOЙ ПPOГPAMMЫ C* BO BPEMEHHOЙ БИБЛИOTEKE. C* C* ИЗ-ЗA OTCYTCTBИЯ B ФOPTPAHE PEKYPCИИ C* PEKYPCИBHЫE ПO CBOEЙ CYTИ BЫЗOBЫ C* ПOДПPOГPAMM ПPИXOДИTCЯ ПOДMEHЯTЬ C* OБPAЩEHИEM K KOПИЯM ЭTИX ПOДПPOГPAMM, C* ИMEЮЩИM ДPYГИE ИMEHA. ПPИ ЭTOM C* ЧИCЛO KOПИЙ ДOЛЖHO COOTBETCTBOBATЬ C* ГЛYБИHE PEKYPCИИ. C* ПPOГPAMMA BREEDING ПPEДCTABЛЯET C* ИЗ CEБЯ MEXAHИЗM ДЛЯ ПOPOЖДEHИЯ HYЖ- C* HOГO KOЛИЧECTBA TAKИX KOПИЙ. ПPOГ- C* PAMMA C ИMEHEM NAME PAЗЫCKИBAETCЯ C* BO BPEMEHHOЙ БИБЛИOTEKE (ИЛИ CPEДИ C* ЗAKAЗAHHЫX OБCП). ЗATEM KATAЛOГ C* BPEMEHHOЙ БИБЛИOTEKИ ДOПOЛHЯETCЯ C* ИMEHAMИ N1,N2,...,NN, ПPИЧEM C* YKAЗATEЛИ MECTOПOЛOЖEHИЯ ПPOГPAMM C* N1,N2,...,NN ДYБЛИPYЮT YKAЗATEЛЬ C* ДЛЯ NAME. C*
*CALL BREEDING:NOTEXIST(FOO) OTCYTCTBYET : NOTEXIST, но если дать существующую, то тихо ничего не делает
*CALL BREEDING:BREEDING(FOO) *CALL TCATALOG 17 ABГ 25 14.25 TEMPORARY LIBRARY CBOБOДHO 21 03 25 BREEDING 21 02 00 00106